| | U.S. Central | text only | |
| Thursday, October 18 |
| 7:20p |
6 |
Seattle Seahawks (11-5) |
at |
13 |
San Francisco 49ers (11-4-1) |
| |
| Sunday, October 21 |
| 12:00n |
14 |
Arizona Cardinals (5-11) |
at |
21 |
Minnesota Vikings (10-6) |
| 12:00n |
13 |
Baltimore Ravens (10-6) |
at |
43 |
Houston Texans (12-4) |
| 12:00n |
13 |
Cleveland Browns (5-11) |
at |
17 |
Indianapolis Colts (11-5) |
| 12:00n |
19 |
Dallas Cowboys (8-8) |
at |
14 |
Carolina Panthers (7-9) |
| 12:00n |
30 |
Green Bay Packers (11-5) |
at |
20 |
St. Louis Rams (7-8-1) |
| 12:00n |
35 |
New Orleans Saints (7-9) |
at |
28 |
Tampa Bay Buccaneers (7-9) |
| 12:00n |
35 |
Tennessee Titans (6-10) |
at |
34 |
Buffalo Bills (6-10) |
| 12:00n |
23 |
Washington Redskins (10-6) |
at |
27 |
New York Giants (9-7) |
| 3:25p |
23 |
Jacksonville Jaguars (2-14) |
at |
26 |
Oakland Raiders (4-12) |
| 3:25p |
26 |
New York Jets (6-10) |
at |
29 |
New England Patriots (12-4) |
| 7:20p |
24 |
Pittsburgh Steelers (8-8) |
at |
17 |
Cincinnati Bengals (10-6) |
| |
| Monday, October 22 |
| 7:30p |
7 |
Detroit Lions (4-12) |
at |
13 |
Chicago Bears (10-6) |
| |
| Open Date: |
| Falcons, Broncos, Chiefs, Dolphins, Eagles, Chargers |
| |
