| | U.S. Central | text only | |
| Thursday, September 20 |
| 7:20p |
36 |
New York Giants (9-7) |
at |
7 |
Carolina Panthers (7-9) |
| |
| Sunday, September 23 |
| 12:00n |
24 |
Buffalo Bills (6-10) |
at |
14 |
Cleveland Browns (5-11) |
| 12:00n |
38 |
Cincinnati Bengals (10-6) |
at |
31 |
Washington Redskins (10-6) |
| 12:00n |
41 |
Detroit Lions (4-12) |
at |
44 |
Tennessee Titans (6-10) |
| 12:00n |
22 |
Jacksonville Jaguars (2-14) |
at |
17 |
Indianapolis Colts (11-5) |
| 12:00n |
27 |
Kansas City Chiefs (2-14) |
at |
24 |
New Orleans Saints (7-9) |
| 12:00n |
23 |
New York Jets (6-10) |
at |
20 |
Miami Dolphins (7-9) |
| 12:00n |
13 |
San Francisco 49ers (11-4-1) |
at |
24 |
Minnesota Vikings (10-6) |
| 12:00n |
6 |
St. Louis Rams (7-8-1) |
at |
23 |
Chicago Bears (10-6) |
| 12:00n |
10 |
Tampa Bay Buccaneers (7-9) |
at |
16 |
Dallas Cowboys (8-8) |
| 3:05p |
27 |
Atlanta Falcons (13-3) |
at |
3 |
San Diego Chargers (7-9) |
| 3:05p |
6 |
Philadelphia Eagles (4-12) |
at |
27 |
Arizona Cardinals (5-11) |
| 3:25p |
31 |
Houston Texans (12-4) |
at |
25 |
Denver Broncos (13-3) |
| 3:25p |
31 |
Pittsburgh Steelers (8-8) |
at |
34 |
Oakland Raiders (4-12) |
| 7:20p |
30 |
New England Patriots (12-4) |
at |
31 |
Baltimore Ravens (10-6) |
| |
| Monday, September 24 |
| 7:30p |
12 |
Green Bay Packers (11-5) |
at |
14 |
Seattle Seahawks (11-5) |
| |
